Adrafinil Review

What is Adrafinil?

Adrafinil is a smart drug used to improve alertness, wakefulness, and mood. It is famously known by its brand name Olmifon. This medicine is discovered in France in the 70’s and is commonly used by people who work in the early mornings or in the graveyard shift.

Adrafinil works in two ways. First, it helps boost the production of the neurotransmitter hypocretin, which is accountable for alertness. Increase your dosage up to a notch, and Adrafinil will also reduce fatigue.

Secondly, this drug improves cognitive performance and memory by breaking down Glutamate, the richest neurotransmitter in the human body.

After a few years of experiment with scientists found out that Adrafinil is in fact, a prodrug to the more popular Modafinil. When we say prodrug, it is a chemical substance which once consumed, gets broken down by the body’s metabolism into metabolites. In this case, Adrafinil gets metabolized into modafinil.

 Adrafinil vs. Modafinil

Adrafinil is the predecessor of Modafinil. These two substances were developed to cure narcolepsy, idiopathic hypersomnia, and to enhance the mental functioning of the elderly. Since these two are related to each other, the two wakefulness promoting compounds have pretty similar effects.

Modafinil is more potent when you compare the two, as Olmifon was taken out of circulation in 2011 by Cephalon. Cephalon is a French pharmaceutical company that bought out Laboratories Lafon, the company that discovered Adrafinil in 1974.

Adrafinil is mainly a cerebral stimulant. This is a smart drug that will give you mental abilities a boost. Also, it will have a little carryover to your motor coordination, unlike other stimulants. A higher level in hypocretin initiates a spike in dopamine, norepinephrine, and histamine which leads to better alertness and focus. Adrafinil is, therefore, a very good study drug.

Meanwhile, modafinil will have the same effects on our productivity as Adrafinil because it is a metabolite. Modafinil is absorbed into our body almost twice as fast.  It usually takes 45 to 60 for Adrafinil to be broken down in the liver as opposed to Modafinil, which only needs about 25 to 40 minutes.

Adrafinil and Modafinil are on the WADA banned substance list since 2004. But, many countries prefer Modafinil over amphetamines for soldiers in combat situations or long missions.

Adrafinil Dosage

Adrafinil is most efficient when taken in doses between 300 and 1200 mg. It is advisable that you have your own scale.

If you choose to buy Adrafinil in powder form, buy a scale and weigh your doses correctly to avoid as many side effects. Start out at 300 mg and gradually work your way up to taking 1200 mg.

Adrafinil is water soluble, so you can mix it into water or juice and drink it on an empty stomach to get the best results.

The best time to take it is early in the morning, other users have reported that they have difficulty falling asleep if they have taken it too late in the day.

Adrafinil is best used lightly or in cycles at the most because it may damage your liver. I recommend taking a week off every two weeks of taking this smart drug.

One will become tolerant against the drug when you take it for the long term, therefore, you’ll have to take more to achieve the same results.

Adrafinil Side Effects

Be cautious in terms of taking drugs. Adrafinil might be a great smart drug for those who need an occasional boost when working long hours or crazy shifts, but taking it on a regular basis is not advisable.

Side Effects of Adrafinil

  • Side effects are quite similar to those of Modafinil such as headaches, elevated blood pressure, nausea, and stomach problems.
  • It may also cause daydreaming and hallucinations.
  • It is a mild appetite suppressant.
  • You should pay attention to Adrafinil’s effect on the liver. It has been proven to increase liver enzymes because it needs to be metabolized in the liver before it actually begins to work. Increased liver enzymes might not be life-threatening, this may have a trickle-down effect on other medical issues you might have.

Again, it is important to be cautious. One must consult a doctor first before taking the smart drug.

How to Stack Adrafinil?

There are few nootropics on the market that have an interactive effect on Adrafanil and make it more powerful. Now, if you are searching for more nootropic stack that you would like to come with your Adrafinil, this list is given to you.

Stack Adrafinil

  • Pramiracetam

Pramiracetam will boost the production of choline, which is then converted into acetylcholine, a significant neurotransmitter in cognitive processes like memory, concentration, and learning speed.

A combination of 100 mg of Pramiracetam with Adrafinil will produce an energy and memory boost without the jitters that some other stimulants might induce.

  • Alpha GPC

Alpha GPC works very similar to Pramiracetam in the sense of raising the body’s choline levels, resulting in more focused and better study or work sessions.

It is quite usual for Alpha GPC users to combine it with Pramiracetam to max out their focus and learning speed. Simply combine 300 mg of Alpha GPC it with Adrafinil and you will be alert and ready for intense mental work.

  • L- Theanine

L-Theanine is an amino acid, commonly found in tea leaves that will certainly benefit Adrafinil users. Many use Adrafinil when facing the target, which means they will be operating at extreme-stress levels. Recent research show L-Theanine offers relaxation and fights fatigue without inducing drowsiness.

Users can stack Adrafinil with about 50 mg of L-Theanine in order to stay focused and up for longer periods of time while reducing anxiety levels brought up by their demanding tasks.

  • Noopept

Noopept is a famous nootropic which helpfully affects your mood and helps fight anxiety. Take 20 mg along with Adrafinil to alert your brains when facing important cognitive tasks and attack them with a calmer and clear mind.

  • Milk Thistle

Milk thistle is something I would definitely recommend when considering your general health. Adding it to your Adrafinil will lessen the strain on your liver. Milk thistle is a natural extract, known in fighting liver damage and taking approximately 50-150 mg will deeply reduce potential risks of liver problems when taking Adrafinil.


Frequently asked questions.

  • What are the benefits of taking Adrafinil?

Adrafinil enhances alertness, motivation and focuses for people who work for longer periods of time or at wee hours of the day.

  • Is it safe taking Adrafinil?

Yes, it is, as long as you follow the prescribed dosages and start out at the lower end of the spectrum, you should be fine.

  • Are there any side effects to taking Adrafinil?

Some users may encounter nausea, stomach problems, headaches, lack of appetite and insomnia.

  • Can I take Adrafinil every day?

Daily use is not advisable; I suggest taking it only when you need it, or cycling it. Give your body a week break after taking it for two weeks.

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